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What Is Acetaminophen?

Acetaminophen is an over-the-counter medication used to reduce pain and fever. Unlike non-steroidal anti-inflammatory drugs (NSAIDs), it does not contain any antihistamines or decongestants. Also known as paracetamol, APAP, or Tylenol, acetaminophen is available in various forms, including tablets, capsules, liquids, suppositories, and topical creams. It is commonly used to treat mild to moderate pain such as headaches, muscle aches, colds, flu, and arthritis.

Acetaminophen blocks chemicals in the body responsible for pain and inflammation. It is generally safer than NSAIDs like ibuprofen and naproxen as it does not cause stomach irritation or ulcers. However, incorrect use can lead to serious side effects, including liver damage. Always read the label carefully and follow dosage instructions from your doctor or pharmacist.

How to Take Acetaminophen

• Read the product label or consult your pharmacist for guidance.
• Take acetaminophen exactly as directed. Do not exceed the recommended dosage.
• Typically taken every 4 to 6 hours, with a maximum of 4 doses per day for fever relief.
• Swallow tablets whole with water; do not chew, break, or crush.
• Avoid exceeding the maximum daily dose unless directed by your doctor.
• Consult your doctor before using acetaminophen if you take other medications.
• If pregnant or breastfeeding, seek medical advice before use.
• Store acetaminophen in a cool, dry place away from moisture and heat.

How Does Acetaminophen Work?

Acetaminophen relieves minor aches and pains by increasing the body’s pain threshold, reducing discomfort. It lowers fever by helping the body eliminate excess heat through its effect on the hypothalamic heat-regulating center in the brain. By inhibiting COX enzymes responsible for producing pain-inducing prostaglandins, acetaminophen effectively reduces pain and inflammation. When taken at recommended dosages, it is generally safe. However, excessive doses or drug interactions can cause serious health issues.

Side Effects of Acetaminophen

Acetaminophen is generally well tolerated, but side effects may include:

• Common side effects: Upset stomach, skin rash, itching, trouble sleeping.
• Serious side effects: Yellowing of the skin and eyes, upper stomach pain, swelling, breathing difficulties, unusual bleeding, or severe skin reactions.

Seek immediate medical attention if you experience severe side effects.

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Drug Interactions

Acetaminophen can interact with various medications, including:

• Anticoagulants (blood thinners)
• Certain antibiotics
• Medications for seizures, mental illness, or Parkinson’s disease
• NSAIDs (aspirin, ibuprofen, naproxen)

Combining acetaminophen with alcohol increases the risk of liver damage. Always consult your doctor before mixing medications.

What to Avoid When Taking Acetaminophen

• Do not exceed the recommended daily dose to prevent liver damage.
• Avoid alcohol consumption while taking acetaminophen.
• If you have pre-existing medical conditions, consult your doctor before use.
• Do not mix with other medications without medical approval.
• If pregnant or breastfeeding, consult your doctor before use.
• Do not administer acetaminophen to children under 12 without medical advice.
• If you have kidney or liver disease, avoid acetaminophen without consulting a doctor.
• If you experience an allergic reaction (e.g., breathing difficulties, hives, swelling), stop use and seek immediate medical attention.

Dosage

Follow dosage instructions carefully:

• Adults: 325-650 mg every 4-6 hours or 1000 mg every 8-12 hours (maximum 4000 mg in 24 hours).
• Children (under 12): Dosage based on weight and age (maximum 5 doses per 24 hours).

Extended-release tablets should be swallowed whole to ensure proper medication release.

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Missed Dose

If you miss a dose, take it as soon as you remember. If it’s close to the next scheduled dose, skip the missed dose and continue as normal. Never take a double dose to compensate for a missed one.

Overdose Risks

Overdosing on acetaminophen can cause severe liver damage or be fatal. Symptoms of overdose include nausea, vomiting, stomach pain, sweating, confusion, weakness, and yellowing of the skin or eyes. Seek emergency medical help immediately if overdose is suspected.

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